Many people still stigmatize those on antidepressants, often downplaying depression’s severity and assuming medication prevents full recovery. Antidepressants are prescribed to treat depression and anxiety, helping millions across Europe manage symptoms and improve daily functioning.
A new study published in The Lancet Psychiatry this week identifies the most effective way to stop taking antidepressants: slow tapering combined with psychological support.
Conducted by researchers in France and Italy, the study reviewed 76 randomized trials involving over 17,000 participants, making it one of the most comprehensive analyses on antidepressant discontinuation to date.
Current guidelines typically recommend continuing antidepressants for six to nine months after symptoms improve, yet many patients remain on medication longer than necessary.
The study’s findings indicate that gradually reducing medication while engaging in therapy is as effective as staying on antidepressants in preventing short-term relapse. Lead author Giovanni Ostuzzi emphasised that discontinuation is feasible for most patients but should be tailored to each patient and guided by a specialist.
The research highlighted that relapse prevention depends on both the pace of tapering and access to psychological support. “Slow tapering” was defined as tapering over more than 4 weeks, while “very slow tapering” was defined as tapering over 12 weeks or more. Combining tapering with therapy could prevent relapse in one out of five patients compared with abrupt discontinuation or tapering in under four weeks.
These findings offer hope to individuals who feel ready to attempt life without antidepressants. They also aim to empower patients and clinicians with evidence-based strategies for safe and effective medication discontinuation.
By prioritizing personalized tapering schedules and ongoing psychological support, patients can reduce relapse risk and regain confidence in managing their mental health independently.
